By Steven Novella, MD, Yale School of Medicine
How dangerous are GMOs? Just about all the plants and animals that you think of as food have been extensively cultivated over centuries or even thousands of years by human ingenuity. They never existed in nature before human tampering. How much cultivation is required before food no longer considered natural?

Consider a Carrot
How dangerous are genetically modified organisms (GMOs)? Consider the example of the carrot, interesting historical example because wild carrots still exist today. You probably have seen them as they’re a common weed. In the United States, they’re known as Queen Anne’s Lace. It has a pretty white flower on top. If you’ve ever pulled one out of the ground and smell the root, it smells like a carrot.

You can eat it and gain some nutrition from these wild plants. But, parts of it are too fibrous to eat and the amount of nutrition you get out of it is minimal. However, this wild carrot was cultivated for centuries to be larger, sweeter, and less fibrous until eventually, we end up with the carrot that we are familiar with today. Even then, by the 15th and 16th centuries, there were white, yellow, purple, and black carrots.
The orange carrot emerged at least by the 16th century, perhaps earlier; though it’s still not clear. At some point along the line, probably in a cultivar of yellow carrot, there was a mutation that dramatically increased the amount of beta carotene in this crop making the carrot orange. This became popular then because the orange cultivar is much more nutritious because of the beta carotene.
This is a transcript from the video series Medical Myths, Lies, and Half-Truths: What We Think We Know May Be Hurting Us. Watch it now, on Wondrium.
Modern Day GMs
But, what about genetically modified (GM) food now? We can dramatically change plants by cultivating them. Is genetic modification any different? It is a lot quicker and more powerful. We can take genes even from distantly related species, even bacteria, and place a bacterial gene in a crop plant. Therefore, there are differences between genetically modifying food and just cultivating them. But, it is still just another technology or thing that humans do to alter, even significantly, food.
Some people object to the very notion of GM food. There are other issues, including political issues, regarding ownership of that food. Today we’re discussing the health and safety of the food itself. The point is that, whether it’s the result of natural evolution, cultivation, or genetic modification, the product is what matters the most—not necessarily how we got to that product.
Learn more about the importance of whole foods and fiber
Food Irradiation
What about irradiating food? Some people oppose the notion of passing radiation through food because it’s not natural and it may alter the food from its natural state. However, it’s a myth that irradiated food is radioactive. It is not. While the radiation passes through the food, there is no radioactive material in the food itself. But, that is not the extent of concerns that people have about irradiated food.

Here is a quick review of what this technology entails. There are several different methods to irradiate food. There is gamma irradiation technology that uses high energy gamma rays emitted from radioactive material like Cobalt 60 or Cesium 137; electron beam irradiation which uses beta rays; and x-ray irradiation, which is more deeply penetrating than electron beam radiation. This last method also doesn’t require any radioactive material or source, therefore, it is easier to use.
Irradiating food is very effective in preserving food because it kills most of the bacteria contaminating the food. It’s so effective that you can store irradiated milk in the cupboard; it doesn’t even need to be refrigerated and it won’t spoil for weeks. It is true that due to irradiation, because high energy particles are passing through the food, may break down some nutrients like thiamine. But, overall there is a minimal effect on the food itself. These effects are similar to cooking in terms of, for example, the production of oxidants in the food. It’s not much different than just cooking the food itself.
Learn more about the controversies surrounding genetically modified plants
Benefits of Food Irradiation
The Centers for Disease Control estimates that, if we irradiated 50 percent of the meat and poultry in the United States, this would prevent nearly 900,000 cases of infection, 8,500 hospitalizations, and over 6,000 catastrophic illnesses with 350 deaths each year. The effectiveness of irradiating food is not in question. But, most of the opposition to it is based on the notion that it’s doing something harmful to the food and altering it from its natural state.
Learn more about some common fallacies about the “natural foods” you find in almost any grocery store around the world
Common Questions About the Dangers of GMOs
GMO’s are often made to enhance the traits of the original plant and to create a product that must be purchased repeatedly.
Herbert Boyer and Stanley Cohen were the first engineers of genetically modified organisms in 1973.
There were 26 species identified as GMO in 2015. In 2018, it is proposed that only 10 are GMO.
John Francis Queeny started Monsanto on September 26, 1901, in St. Louis, MO.